Phone: 312-413-7743
 Fax: 312-413-7803
 E-Mail: linninge@uic.edu
 Research Web Page: http://vienna.bioengr.uic.edu/

 Ph.D., Vienna University of Technology, 1992
 Postdoc, University of California at Berkeley, 1992
 Research Associate, Massachusetts Institute of Technology, 1997

Associate Professor of Chemical Engineering and Bioengineering, UIC
Visiting Research Faculty, Department of Surgery, Section Neurosurgery, University of Chicago

• Awards and Honors

• Publications

• Research Group Site

• Laboratory for Product and Process Design

Research Interests

Research projects are in the areas of complex system design and analysis. Our research advances mathematical modeling and computational methods in process design and optimization, integrated design and control and systems biology. Current research projects include

1. Integrated design and control of uncertain systems

This work aims at creating chemical processes for flexible dynamic performance by optimally balancing design and   control decisions.

2. Problem inversion of distributed systems

3. Synthesis of separation networks

Our research group is also engaged in interdisciplinary research on the human brain with the University of Chicago hospitals. Research projects address:

4. Invasive drug delivery into the human brain

5. Intracranial dynamics in the human brain

Books

Korovessi, E;  Linninger, A. A., Ed. (2005). Batch Processes. Chemical Industries Series, Taylor&Francis, CRC Press.

Recent Publications

Linninger, A.A.; Xenos, M.; Zhu, D.C.; Somayaji, MB.R.; Kondapalli, S. and Penn, R.D., "Cerebrospinal Fluid Flow in the Normal and Hydrocephalic Human Brain", IEEE Transactions on Biomedical Engineering, Jan-2006- In Press

Linninger, A.A.; Tsakiris, C.; Zhu, D.C.; Xenos, M.; Roycewicz, R.D.; Danziger, Z. and Penn, R.D., "Pulsatile Cerebrospinal Fluid Dynamics in the Human Brain", IEEE Transactions on Biomedical Engineering, 52 (4), 557-565, 2005.

Penn, R.D.; Lee, M.C.; Linninger, A.A.; Miesel, K.; Lu, S.N. and Stylos, L., "Pressure Gradients in the Brain: An Experimental Model of Hydrocephalus",  J.Neurosurgery, 02, 1069-1075, 2005.

Malcolm, A.; Zhang, L. and Linninger, A. A., "Design of Environmental Regulatory Policies for Sustainable Emission Reduction", AIChE J, 52(8), 2792-2804, 2006.

Zhang, L. and Linninger, A. A., "Towards  Computer-aided Separation Synthesis", AIChE J, 52(4), 1392-1409, 2006.

Tang, W.; Zhang, L.; Linninger, A. A.; Tranter, R. and Brezinsky, K., "Solving Kinetic Inversion Problems via a Physically Bounded Gauss-Newton (PGN) Method", Ind. Eng. Chem. Res., 44(10), 3626-3637, 2005.

Chowdhry, S.; Krendl, H., and Linninger, A. A., "Symbolic Numeric Index Analysis Algorithm for Differential Algebraic Equations", Ind. Eng. Chem. Res., 43, 3886-3894,2004.

Chakraborty, A.; Malcolm, A.; Colberg, R. D. and Linninger, A. A., "Optimal Waste Reduction and Investment Planning under Uncertainty", Comp. Chem. Eng., 28(7), 1145-1156, 2004.

Chakraborty, A., and Linninger, A. A., "Plant-Wide Waste Management. 3. Long Term Operation and Investment Planning under Uncertainty", Ind. Eng. Chem. Res., 42, 4772-4788, 2003.

Chakraborty, A., and Linninger, A. A., "Plant-Wide Waste Management 2. Decision Making under Uncertainty", Ind. Eng. Chem. Res., 42, 357-369, 2003.

Chakraborty, A., and Linninger, A. A., "Plant-Wide Waste Management. 1. Synthesis and Multi-Objective Design", Ind. Eng. Chem. Res., 41 (18), 4591-4604, 2002.